O-091 The impact of endocrine disruptors on early pregnancy and clinical outcomes in IVF

Abstract The impact of endocrine disruptors on early pregnancy and clinical outcomes in IVF Moncef Benkhalifa (1,2,3), Debbie Montjean (2), Hafida Corsi-Cauet (3), Henri Copin (1,3), Véronique Bach Pierre Miron Rosalie Cabry (1,3) (1) Reproductive Medicine Genetics, University Hospital & School Medicine. Picardie Jules Verne. Amiens France (2) ART Centers. Laval Brossard. Fertilys International Inc. Laval. Québec. Canada (3) PERITOX Laboratory. Amiens. Since more than 40 years, there are annual increasing studies, meta-analysis reporting discussing the potential associations between disrupting chemicals (EDCs) human fertility declining. Today it’s accepted that a substantial number environmental exposition factors affect fecundity capacity couples during peri post conception period. It’s most EDCs interfere with or mimic steroid hormone action; predominantly by affecting estrogen, androgen thyroid hormones signaling pathways disturbing specific molecular process relation single multiple biological functions. Some can interact male female reproductive system lead to disruption testis ovary. they exert their effects mainly via binding transcription factor receptors, alter function through variety mechanisms. At age may expression and/or activity enzymes required for synthesis catabolism testicular ovarian sex steroids receptors ability bind endogenous ligands. For example, male, literature reported negative correlation disrupted spermatogenesis lifestyle (environmental-professional expositions) such as alcohol consumption, cigarette smoking, drug use, obesity caused high-energy diet. In infertility diseases, ED has been studied animals. Many disorders have described, low weight, impaired folliculogenesis, high aneuploidy rate acceleration follicular atresia. Indeed, women exposed some endocrine-disrupting pesticides (such atrazine, lindane) an elevated risk long menstrual cycles anovulation but serious consequence is POF endometriosis pathophysiology’s. our experience region (France), we observed various action associated poor oocyte quality (maturation competency), embryonic defects outcomes, pesticide compounds linked causes infertility, premature insufficiency, polycystic syndrome, endometriosis. It was reduce embryo implantation chances increase miscarriage, placenta post-natal abnormalities. endometrium receptivity failure play modifying keys elements immune response relevant pregnancy, disrupt tolerance robust placentation, optimal fetal development be contributing recurrent preeclampsia, preterm birth related pathologic gestation Environmental insults, including critical periods development, DNA methylation patterns, leading inappropriate developmental gene disease risks. Similar factors, influence without sequence. commonly transgenerational inheritance parentally acquired traits conveyed epigenetic alterations risks also known “epimutations”. Conclusion, exposure becoming now worldwide public health. community should informed about decline, ongoing rates, miscarriage doses example. We must keep mind humans mixtures composed hundreds every day not chemical isolation.